A child is the greatest blessing

Overview

PGD is a technique that provides information about the gene make-up of the cells found in an embryo (a fertilized egg). An embryo biopsy removes about 3-8 cells from each day 5 embryo (a blastocyst), and then cells are sent to a lab for testing. The embryo is usually frozen and implanted later. PGD can be used to identify approximately 2,000 inherited single gene disorders and is 98 per cent accurate in identifying affected and unaffected embryos.

PGS is used to determine whether the cells in an embryo contain the normal number of chromosomes, which is 46. After an embryo grows in the lab, it is usually biopsied on day 5 (blastocyst stage). A few embryo cells are then sent to an external lab which uses technology to count the number of chromosomes within each cell. Embryos with a normal number of chromosomes are “euploid” and those with an abnormal number are “aneuploid.” The purpose of PGS is to avoid transferring an abnormal embryo into the uterus.

Procedure

  • Genetic testing of the parents
  • Designing of primers for PGD
  • Planning an IVF cycle
Egg retrieval
  • IVF / ICSI process
  • Embryo grading
  • Blastocyst culture
  • Embryo biopsy of trophectoderm cells
  • Sending the sample to a genetic lab
  • Carrying out the test
  • Reporting
  • Genetically healthy embryos are selected
  • Embryo transfer

Advantages

  • We are the first and foremost IVF Center offering PGD – Pre implantation genetic diagnosis in Chennai India.
  • We do day 3 and day 5 ( Blastocyst ) biopsy.
  • NGS Technology – Next Generation Sequencing with 100% accurate results.
  • We have experienced team handling PGD in our IVF center.
  • 100% Genetic detection rate.
  • PGD for disorders like Sickle cell anemia, Thalassemia, Spinal Muscular dystrophy are offered routinely.

FAQ’s

The procedure is not painful as it is done under light sedation, but may cause mild discomfort. At our clinic, we use mild anesthesia administered through an IV route which relieves discomfort.

IVF is likely to be recommended for the following fertility problems:
1. If you have blocked or damaged fallopian tubes
2. If your partner has male infertility issues like Oligozoospermia, Teratozoospermia or Athenozoospermia.
3. If you have premature ovarian failure
4. If you have been trying to conceive for at least two years and a cause hasn’t been found to explain why you have not become pregnant.

1. Women with a tubal problem
2. Women with unexplained fertility
3. Women with severe endometriosis
4. Couples with male factor infertility

Before treatment start, you will discussmedical history and the treatment processincluding risk and side effects kith your doctor.
1. Stimulation- After your baseline scans, injections will stimulate your ovaries to develop multiple eggs
2. Monitoring- Regular scans and blood test allow us to monitor your ovanan response to the drug
3. Trigger injections- When hormones are at the right levels another injection will trigger the eggs to mature
4. Egg collection and sperm collection- Eggs are collected via a needle passed through the vagina whilst you are under sedation. A semen sample is required on the day of egg collection
5. Fertilization and embryo development- Eggs and sperm are placed P an incubator to fertilize. Embryo development is monitored by CRGH embryologist
6. Embryo transfer- The best ennbryo(s) 6 /are transferred back into the uterus. Any suitable embryo not transferred can be frozen for Later use
7. Pregnancy test- Patient takes a pregnancy test 16 days after embryo transfer. At this stage we will arrange appropriate support.

So the point is that the IVF success rate could vary based on the denominator used to calculate the IVF cycle outcome. Its always preferable to always define the success rate using all the available denominators and discuss every one of them with the couple. The couple should be able to understand the sucess chances for their particular condition. There are even more denominators like age, number of embryos transfered, frozen or fresh emebto transfer, ICSI, PGD / PGS tested embryos etc. This further gets complicated when each ivf clinic or ivf doctor in the center wants to boos their success rates to showcase themselves in this highly competitive era.

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